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The endocannabinoid system has CB1 and CB2 receptors on every organ in the body, including your stomach, esophagus, and throughout your digestive tract. 2 Another animal study from 2002 used a synthetic cannabinoid receptor agonist (not a phytocannabinoid ) to measure the activity of the CB1 and CB2 receptors on esophageal relaxation.
The researchers used obesity data in Washington State between 2002-2018 because it is one of the first states to have legalized recreational or adult-use cannabis. digestive problems such as heartburn or gallbladder disease, sleep apnea, osteoarthritis and are even at the risk of presenting with more severe covid-19 symptoms. .
An important point to highlight is the study recently published on the Cannabis and Cannabinoid Research website (June 2016) which shows that orally taken CBD may turn into THC due to the action of the digestive juices in the stomach. Thus, using CBD sublingually (under the tongue) is recommended so it does not reach the digestive system.
However, keep in mind that because of the digestion process, edibles need more time to kick in compared to smoking. Clayton N, Marshall FH, Bountra C, O’Shaughnessy CT; CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain; Pain; April 2002; 96(3):253-60.
In regards to the Biblical tradition, it has even been suggested by scholars, that the Biblical Prophet Ezra, used Persian infused wine, or haoma as a means of entheogenic induction ( Brown, 1890; Dobroruka, 2002 ).
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