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Using psilocybin in small doses, or microdosing, has been shown to aid in the treatment of various mental health issues, including anxiety, depression, PTSD, and obsessive-compulsive disorder. In 2006, the first research paper by Johns Hopkins was published on the positive long-term impact of using psilocybin in a therapeutic study.
The percentage of Americans over 65 who had reported using cannabis in the past year had increased tenfold between 2006 to 2018, from 0.4% Microdosing” cannabis is gaining popularity as a way to treat a number of ailments such as pain and nausea, without experiencing any intoxicating effects. And unlike THC, it does not make you high.
As the study authors explain: Our theory suggests that the psychoactive effects of CB1 receptor stimulation with THC may be a necessary accompaniment to cannabis-induced weight loss, because down-regulation of CB1 receptors is required for reduced BMI, and it is not yet clear whether microdosing will cause down-regulation.
2006): Another fMRI-enabled psychedelic study investigated the idea that MDMA users may be more impulsive than people that haven’t consumed the substance. She gave 25 participants 13 micrograms of LSD (a standard amount for a microdose) or a placebo in a double-blind experiment. Valdes et al. Kaelen et al.
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